Production of 2,3-Butanediol from non-detoxified wheat straw hydrolysate: Impact of microbial inhibitors on Paenibacillus polymyxa DSM 365

Lignocellulosic biomass (LB) is a cost-effective, readily available, and attractive substrate to produce 2,3-butanediol (2,3-BD) commercially. Fermentative conversion of non-detoxified wheat straw hydrolysate (WSH) 2,3-BD was investigated using Paenibacillus polymyxa. The results show that P. polymyxa co-utilizes representative LB-derived sugars (glucose, xylose arabinose). Comparatively, fermentations with in cultures containing glucose-xylose-arabinose the ratio 8:11:1 resulted 1.03- 1.18-fold increases yield productivity, respectively, relative glucose-only (control). Subsequently, batch were conducted 60 %, 80 100 % WSH control. exhibited considerable tolerance lignocellulose-derived microbial inhibitory compounds (LDMICs) WSH, as evidenced by growth, which increased 1.16-, 1.26- 1.32-fold, when compared concentrations 32, 31 23 g/L respectively. These compare favorably 32 produced control without LDMICs. In addition, evaluation ability transform LDMICs showed has capacity use HMF carbon source. underscore potential for situ detoxification large-scale fermentation 2,3-BD.